Cardioprotective Effects of LCZ696 (sacubitril/valsartan) After Experimental Acute Myocardial Infarction
نویسندگان
چکیده
Masanobu Ishii, MD, Koichi Kaikita, MD, PhD, Koji Sato, MD, PhD, Daisuke Sueta, MD, PhD, Koichiro Fujisue, MD, PhD, Yuichiro Arima, MD, PhD, Yu Oimatsu, MD, Tatsuro Mitsuse, MD, Yoshiro Onoue, MD, PhD, Satoshi Araki, MD, PhD, Megumi Yamamuro, MD, PhD, Taishi Nakamura, MD, PhD, Yasuhiro Izumiya, MD, PhD, Eiichiro Yamamoto, MD, PhD, Sunao Kojima, MD, PhD, Shokei Kim-Mitsuyama, MD, PhD, Hisao Ogawa, MD, PhD, Kenichi Tsujita, MD, PhD
منابع مشابه
Prevention against renal damage in rats with subtotal nephrectomy by sacubitril/valsartan (LCZ696), a dual‐acting angiotensin receptor‐neprilysin inhibitor
Although patients with chronic kidney disease (CKD) are at increased risk for end-stage renal disease and cardiovascular events, adequate drug therapies for preventing the deterioration of these conditions are still not established. This study was undertaken to evaluate a preventive effect of an angiotensin receptor-neprilysin inhibitor sacubitril/valsartan (LCZ696), which is converted to sacub...
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BACKGROUND There is a paucity of data about the mechanisms by which sacubitril/valsartan (also known as LCZ696) improves outcomes in patients with heart failure. Specifically, the effects of sacubitril/valsartan on vascular function and NO bioavailability have not been investigated. We hypothesized that sacubitril/valsartan therapy increases circulating NO levels and improves vascular function ...
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Salt-sensitive hypertension (SSH) is characterized by impaired sodium excretion and subnormal vasodilatory response to salt loading. High dietary sodium intake and genetic predisposition to salt sensitivity of blood pressure (BP) are of particular clinical relevance in Asian populations. Sacubitril/ valsartan (LCZ696), a first-in-class angiotensin receptor neprilysin inhibitor, was hypothesized...
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BACKGROUND Patients with heart failure (HF) are at high risk for hospital readmission in the first 30 days following HF hospitalization. OBJECTIVES This study sought to determine if treatment with sacubitril/valsartan (LCZ696) reduces rates of hospital readmission at 30-days following HF hospitalization compared with enalapril. METHODS We assessed the risk of 30-day readmission for any caus...
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تاریخ انتشار 2017